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Analgesics in pregnant women

September 6, 2013 – 11:04
Analgesics in pregnant women

Abstract The thalidomide tragedy of the late 1950s clearly proved the need for caution, and questionable drug use should always be avoided. The teratogenic potential of a drug is related to dosage and time of administration. During blastogenesis, fetal death may occur; during embryogenesis, deformity may develop; and during the last trimester, functional anomalies or covert embryopathy may be seen. Finally, the benefit to risk ratio of every drug …

Analgesics safe for kidney disease

September 6, 2013 – 11:04
Analgesics safe for kidney disease

How to CiteKuo, H.-W., Tsai, S.-S., Tiao, M.-M., Liu, Y.-C., Lee, I.-M. and Yang, C.-Y. (2010), Analgesic use and the risk for progression of chronic kidney disease. Pharmacoepidem. Drug Safe., 19: 745–751. doi: 10.1002/pds.1962 Author Information 1Graduate Institute of Occupational Safety and Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan 2 Division of Nephrology, Department of Internal Medicine, Yuan s General …

Are analgesics safe

September 6, 2013 – 11:05
Are analgesics safe

Source Division of Rheumatology, Roy and Lucille Carver College of Medicine, University of Iowa Health Care E330 GH, 200 Hawkins Drive, Iowa City, IA 52242, USA. ppeloso@adelphia.net Abstract OBJECTIVE: To evaluate the analgesic efficacy and safety of tramadol 37.5 mg/acetaminophen 325 mg (tramadol/APAP) combination tablets for treatment of chronic low back pain (LBP). METHODS: This 91 day, multicenter, outpatient, randomized, double blind, placebo …

Analgesics contraindicated in children

September 6, 2013 – 11:04
Analgesics contraindicated in children

Article date: July 2013 Summary Codeine should only be used to relieve acute moderate pain in children older than 12 years and only if it cannot be relieved by other painkillers such as paracetamol or ibuprofen alone. Furthermore, a significant risk of serious and life-threatening adverse reactions has been identified in children with obstructive sleep apnoea who received codeine after tonsillectomy or adenoidectomy (or both). Codeine is now contraindicated …