Analgesic ear Drops in Pakistan

Ear Drops Drug Information, Professional

September 6, 2013 – 11:04

Ear Nose Throat



INN:

Antipyrine—Phenazone. {01}BAN:
Antipyrine—Phenazone. {01}

JAN:
Benzocaine—Ethyl aminobenzoate. {01}
VA CLASSIFICATION
Primary: OT400
Secondary: OT300

Commonly used brand name(s): A/B Otic; Allergen; Analgesic Otic; Antiben; Auralgan; Aurodex; Auroto; Dolotic; Ear Drops; Earache Drops; Otocalm.

Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s).

Category:

Analgesic-anesthetic (otic)—

cerumen removal adjunct—

Indications
Unaccepted
Antipyrine and benzocaine otic combination has been used to relieve pain and inflammation in the congestive and serous stages of acute otitis media {02} {03} {12} {13} and to facilitate removal of cerumen from the wall of the ear canal. {02} {12} However, it is no longer recommended for these purposes, {06} {07} because of questionable effectiveness and because benzocaine frequently causes contact dermatitis.

Pharmacology/Pharmacokinetics

Physicochemical characteristics:

Chemical group—
Antipyrine: A pyrazolone derivative. {05}
Benzocaine: An aminobenzoic acid (para-aminobenzoic acid; PABA) derivative. {01}
Molecular weight—
Antipyrine: 188.23 {01}
Benzocaine: 165.19 {01}
Glycerin: 92.09 {01}
Mechanism of action/Effect:

Both antipyrine and benzocaine are employed for their analgesic/local anesthetic effects. {02} The anhydrous glycerin vehicle is hygroscopic and may provide a decongestant action. {02}

Precautions to Consider
Cross-sensitivity and/or related problems

Patients sensitive to benzocaine or other ester-derivative anesthetics may be sensitive to this medication also. {01}
Carcinogenicity/Mutagenicity

Studies have not been done. {02} {12}
Pregnancy/Reproduction

Pregnancy—
Studies in humans have not been done. However, problems have not been documented. {02} {12}

Studies in animals have not been done. {02} {12}

FDA Pregnancy Category C. {02} {12}
Breast-feeding

It is not known whether this medication is distributed into breast milk. {02} {12} However, problems in humans have not been documented.
Pediatrics

The risk of benzocaine-induced methemoglobinemia may be increased in infants, {05} especially infants up to 3 months of age. However, pediatrics-specific problems that would limit the usefulness of antipyrine and benzocaine combination in older children are not expected.

Geriatrics

Appropriate studies on the relationship of age to the effects of antipyrine and benzocaine combination have not been performed in the geriatric population. However, no geriatrics-specific problems have been documented to date.
Medical considerations/Contraindications
The medical considerations/contraindications included have been selected on the basis of their potential clinical significance (reasons given in parentheses where appropriate)— not necessarily inclusive (» = major clinical significance).

Source: www.drugs.com


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