3 non Opioid analgesics

Novel nonopioid non-antiinflammatory analgesics: ... [J Med Chem. 1993] - PubMed

September 6, 2013 – 11:05

Past Dinner Meetings

Abstract

A series of 3-(aminoalkyl)- and 3-[(4-aryl-1-piperazinyl)alkyl]oxazolo[4, 5-b]pyridin-2(3H)-ones were prepared from their respective oxazolo[4, 5-b]pyridin-2(3H)-ones. Several members of this group were found to possess potent analgesic activity in the mouse during a p-phenylquinone writhing induced test. Among them, phenylpiperazine compounds with two-carbon length alkyl chains, 2a and 2b, appeared by high analgesic with little toxicity having neither an antiinflammatory effect nor opioid receptor affinity. The synthesis and structure-affinity relationships for this series are detailed.

Source: www.ncbi.nlm.nih.gov

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