Analgesics in pregnancy and Lactation

Acetaminophen / hydrocodone Use During Pregnancy and Breastfeeding

June 24, 2014 – 10:00 pm

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Acetaminophen / hydrocodone is also known as: Anexsia, Co-Gesic, Dolacet, Duocet, Hycet, Hydrocet, Liquicet, Lorcet 10/650, Lorcet HD, Lorcet Plus, Lortab, Lortab 10/500, Lortab 2.5/500, Lortab 5/500, Lortab 7.5/500, Maxidone, Norco, Stagesic, Vicodin, Vicodin ES, Vicodin HP, Xodol, Zamicet, Zolvit, Zydone

Acetaminophen / hydrocodone Pregnancy Warnings

Acetaminophen-hydrocodone has been assigned to pregnancy category C by the FDA. Hydrocodone has not been formally assigned to a pregnancy category by the FDA. Detailed information about the use of hydrocodone in pregnancy is not available. Animal studies have reported the occurrence of teratogenic effects at doses 700 times the human dose. Withdrawal symptoms and respiratory depression have been reported in neonates whose mothers took other narcotic analgesics during pregnancy. Hydrocodone should only be given during pregnancy when benefit outweighs risk. Acetaminophen has not been formally assigned to a pregnancy category by the FDA. It is routinely used for short-term pain relief and as an antipyretic in all stages of pregnancy. Acetaminophen is believed to be safe in pregnancy when used intermittently for short durations. Acetaminophen should only be given during pregnancy when need has been clearly established.

Acetaminophen / hydrocodone Breastfeeding Warnings

There are no data on the excretion of hydrocodone into human milk. Other narcotic analgesics are excreted into human milk in small amounts. Acetaminophen is excreted into human milk in small concentrations. One case report of an adverse effect (involving a rash) has been reported in nursing infants. Acetaminophen is considered to be compatible with breast-feeding by the American Academy of Pediatrics.

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