Analgesics effects on the body

The effects of naloxone on body rotation-induced analgesia and anorexia in male mice

July 18, 2014 – 02:01 am

Cryotherapy, effects on body

  • Department of Psychology and Division of Oral Biology-Faculty of Dentistry University of Western Ontario, London, Ontario, Canada N6A 5C2
Received 17 January 1989Available online 7 November 2002AbstractThe effects of body rotation in a horizontal plane and the opiate antagonist, naloxone, on the nociceptive responses and the feeding behavior of male mice were examined. In the first experiment the mice were rotated (70 rpm, schedule of 15 sec on; 5 sec off) for 60 minutes or exposed to sham rotation for the same duration. Midway through the rotation or sham procedure the mice were either injected with naloxone (1 mg/kg) or isotonic saline. At the end of the 60-minute treatment period the animals were placed on a warm surface (47.5°C) and their latency to show a foot-licking response was measured. The rotation procedure produced a significant (p


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